The great apostasy of the sixteenth century, the filtration of heresy into Catholic lands, and the progress of heterodox teachings everywhere, prompted Paul III to establish the "Sacra Congregatio Romanae et universalis Inquisitionis seu sancti officii" by the Constitution "Licet ab initio" of 21 July, 1542. This inquisitional tribunal, composed of six cardinals, was to be at once the final court of appeal for trials concerning faith, and the court of first instance for cases reserved to the pope. The succeeding popes -- especially Pius IV (by the Constitutions "Pastoralis Oficii " of 14 October, 1562, "Romanus Pontifex" of 7 April, 1563, "Cum nos per" of 1564, "Cum inter crimina" of 27 August, 1562) and Pius V (by a Decree of 1566, the Constitution "Inter multiplices" of 21 December, 1566, and "Cum felicis record." of 1566) -- made further provision for the procedure and competency of this court. By his Constitution "Immensa aeterni" of 23 January, 1587, Sixtus V became the real organizer, or rather reorganizer of this congregation.
The Holy Office is first among the Roman congregations. Its personnel includes judges, officials, consulters, and qualificators. The real judges are cardinals nominated by the pope, whose original number of six was raised by Pius IV to eight and by Sixtus V to thirteen. Their actual number depends on the reigning pope (Benedict XIV, Const. "Sollicita et Provida", 1733). This congregation differs from the others, inasmuch as it has no cardinal-prefect: the pope always presides in person when momentous decisions are to be announced (coram Sanctissimo). The solemn plenary session on Thursdays is always preceded by a session of the cardinals on Wednesdays, at the
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